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Health Science and Research – PerSunality

Health Science and Research

Treatment of OSA

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Treatment of OSA with CPAP Is Associated with Improvement in PTSD Symptoms among Veterans.


Posttraumatic stress disorder (PTSD) is common among veterans of the military, with sleep disturbance as a hallmark manifestation. A growing body of research has suggested a link between obstructive sleep apnea and PTSD, potentially due to obstructive sleep apnea (OSA) related sleep disruption, or via other mechanisms. We examined the hypothesis that treatment of OSA with positive airway pressure would reduce PTSD symptoms over 6 months.

Jeremy E Orr, Carolina Smales, Kathleen F Sarmiento
Published in Journal of clinical sleep medicine:

JCSM 2017


Other contributions to the development or execution of research studies

Evidence-Based Design Meets Evidence-Based Medicine: The Sound Sleep Study

National healthcare quality surveys have found that noise in hospitals is an urgent oncern. The purpose of this study was to demonstrate the impact of hospital noise on all stages of human sleep by developing sleep arousal probability threshold curves for specific hospital-based sounds.

VHA Innovation Program: Remote Veteran Apnea

A web-based clinical management pathway for veterans with OSA


Health Science and Research

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Sleep and Neuroscience

Carolina Smales was part of the Medical Chronobiology Program (MCP) at Harvard Medical School and Brigham & Women’s Hospital. Harvard Medical School has a long and distinguished history in basic research in the fields of sleep and circadian rhythms and is home to advanced programs of both clinical care and patient-oriented research on the diagnosis and treatment of sleep disorders.

Review some of Carolina’s publications during her work at the MCP :

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